![]() ![]() ![]() Here we show that introducing lineage branches can circumvent all such limitations, permitting effective attenuation of a wide range of perturbations. These reflect fundamental performance limits dictated by universal conservation-type laws, and are independent of parameter choice. Resultsīy exploring the possible effects of various biologically relevant disturbances on the dynamic and steady state behaviors of stem cell lineages, we find that the simplest and most frequently studied form of lineage feedback - which we term renewal control - suffers from several serious drawbacks. ![]() Experiments and mathematical modeling implicate feedback control of cell lineage progression, but a broad understanding of what lineage feedback accomplishes is lacking. How tissue and organ sizes are specified is one of the great unsolved mysteries in biology. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |